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	Provedor de dados Biol. Res. (1) Autor INESTROSA,NIBALDO C (1) OPAZO,CARLOS (1) RUIZ,FRANCISCA H (1) Palavra-chave Alzheimer’s Disease (1) Amyloid fibrils (1) Aß peptide (1) Copper reduction (1) Oxidative damage (1) Tipo do documento Journal article (1) Ano 2000 (1) País Chile (1) Idioma Inglês (1)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 1 Primeira ... 1 ... Última Amyloid-ß-peptide reduces copper(II) to copper(I) independent of its aggregation state Biol. Res. OPAZO,CARLOS; RUIZ,FRANCISCA H; INESTROSA,NIBALDO C. Alzheimer’s disease (AD) is characterized by the deposition of amyloid b-peptide (Aß) and neuronal degeneration in brain regions involved in learning and memory. One of the leading etiologic hypotheses regarding AD is the involvement of free radical-mediated oxidative stress in neuronal degeneration. Recent evidence suggests that metals concentrated in amyloid deposits may contribute to the oxidative insults observed in AD-affected brains. We hypothesized that Aß peptide in the presence of copper enhances its neurotoxicity generating free radicals via copper reduction. In the present study, we have examined the effect of the aggregation state of amyloid-ß-peptide on copper reduction. In independent experiments we measured the copper-reducing ability of... Tipo: Journal article Palavras-chave: Aß peptide; Amyloid fibrils; Copper reduction; Oxidative damage; Alzheimer’s Disease. Ano: 2000 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602000000200012 Registros recuperados: 1 Primeira ... 1 ... Última

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